睡眠机制知识库

哺乳动物昼夜节律的协调

Coordination of circadian timing in mammals.

综述
作者
Reppert SM, Weaver DR
期刊
Nature
出处
2002; 418(6901); 935-941
DOI
10.1038/nature00965
PMID
12198538
被引
3237

一句话摘要

综述哺乳动物昼夜节律系统的组织方式:各组织由细胞自主的分子振荡器驱动,再由视交叉上核这一中枢时钟依据光照输入统一协调。

为什么重要

确立了「中枢起搏器 + 外周振荡器」的分层架构,是理解生物钟如何既保持组织自主性又维持全身一致的框架性文献。

英文摘要原文

Time in the biological sense is measured by cycles that range from milliseconds to years. Circadian rhythms, which measure time on a scale of 24 h, are generated by one of the most ubiquitous and well-studied timing systems. At the core of this timing mechanism is an intricate molecular mechanism that ticks away in many different tissues throughout the body. However, these independent rhythms are tamed by a master clock in the brain, which coordinates tissue-specific rhythms according to light input it receives from the outside world.

所属章节

昼夜节律与视交叉上核、分子钟

昼夜节律 视交叉上核 分子钟 外周振荡器

条目编号 P009 · 元数据经 Crossref / Europe PMC 回查