尖波-涟漪簇增强海马-新皮层互动以促进记忆巩固

Hippocampal sharp wave-ripples (SPW-Rs), neocortical slow oscillations, and thalamocortical sleep spindles are hypothesized to provide a temporal framework for coordinated information transfer during memory consolidation. Hippocampal replay supports this process, yet replayed sequences often unfold across multiple SPW-Rs, suggesting that individual ripples may not constitute the fundamental unit of hippocampal output. Here, using large-scale electrophysiological recordings from the hippocampus and retrosplenial cortex, we show that hippocampal output is organized into clusters of SPW-Rs (cSPW-Rs) during UP states, which are often phase-locked to spindle troughs. Extending this approach with wide-field imaging and unsupervised latent-variable modeling, we found that cSPW-Rs enhanced segregation between the default mode and somatomotor networks and preferentially replayed spatially extended maze trajectories following learning. We propose that SPW-R clusters enable reverberating hippocampal-cortical spike exchange and the concatenation of sequential experiences, establishing ripple clusters as a previously unrecognized syntactic unit of hippocampal-neocortical dialogue.